What is general guide lines for EPA area, where live AC and DC equipment is used?
If personnel are handling ESD sensitive devices, the general guidelines are the same as for any other ESD Protected Area. See my ESD Guide.
However where high voltages are present there may be a safety concern about earthing the body either through a wrist strap or through conductive footwear and flooring. In this case the risks must be evaluated and if necessary, the ESD precautions modified to reduce safety risks to an acceptable level.
Usually, wrist straps and footwear for ESD use have a minimum of 750k ohm resistance, which is designed to give some protction for up to 250Vac systems. For higher voltages higher resistance (pro rata) can be used if desired. If the risk of shock is unnacceptabe it may be necessary to avoid grounding personnel and use other ESD protection methods. There is no general advice on this as far as I am aware.